"The 7th World Congress for Hair Research was held in Edinburgh, Scotland from May 4th to 6th. A total of 597 clinicians, investigators, surgeons, patient representatives and industry personnel from 47 countries gathered together to discuss recent innovations in the field of hair research. "
"Primary cilia-mediated cellular signaling in dermal papilla cells
K Matsushima1, M Suematsu1, C Mifude1, S Aramaki2, M Tanaka2, T Yasunaga2 and K Kaseda1 1Saravio Central Inst., Saravio Cosmetics Ltd., Beppu, Japan and 2Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Japan"
研究者の方の名前と研究機関ですね。Saravio Cosmetics Ltdの名前があります。
"Dermal papilla cells (DPC) produce various intercellular signaling molecules and thereby play essential roles in hair growth and development. Great amount of attention has been paid to an antenna-like organelle (primary cilium) as a signaling center in mammalian cells. However, little is known about the roles of primary cilia in DPC. Here we show that the DPC cilium is involved in producing cell growth signals. Immunochemistry, together with electron microscopic observations, showed that primary cilia protruded from cultured human follicle DPC. The ciliary length was distributed around 2μm and the diameter was approximately 0.2μm, which is in good agreement with previous observations in other mammalian cells. In order to investigate a role of the organelle in intercellular signaling, mesenchymal stromal cells were grown in DPC-pretreated media under different conditions and the cellular viability was quantified. In the presence of lithium chloride, the cilia length of DPC became longer and the mesenchymal stromal cells became more viable. In contrast, shortening of DPC cilia by KIF3A knockdown reduced the viability of the mesenchymal cells. These results suggest that cilium-based signaling in DPC plays a key role in maintaining other cells. We are currently trying to identify candidates that regulate cilia structure and its signaling function. Understanding the primary cilia of DPC could provide fundamental insight into hair regulation and a clue towards the future clinical application."